Lab-on-a-chip device made by autohesion-bonded polymers

Lab-on-a-chip device made by autohesion-bonded polymers

Polymers have the obvious advantages of flexibility in design and cost effectiveness to fabricate a lab-on-a-chip (LOC) device. Polyether ether ketone (PEEK) in particular is very attractive choice as it adds biocompatibility in addition to the possibility of hematic sealing in a 3D design. Hereby, we extend our previous successful technology of autohesive hermetic bonding of medical implants i...

Liver Specific Function Enhancement by Microvascular System Integrated within a Lab-on-chip Device

We report a lab-on-chip device to study liver function enhancement by mimicking a liver tissue with its sinusoid on a 3D biomimetic chip. The device procures a thin polydimethylsiloxane membrane with an array of holes etched in it and sandwiched in the center of the microchannel to form upper and lower microchambers. Hepatocytes and fibroblasts were co-cultured on the upper chamber to mimic liv...

Lab - on - a - Chip Technology —

Hybridoma: On-chip Cell Fusion Lab in a Tube Lab on a Chip

Antibodies have been used for many different applications ranging from basic biological studies to therapeutics. For example, antibodies are used in treatments as wide ranging as cancer care, autoimmune disease therapy, and to prevent rejection of transplanted organs. This requires large quantities of antibodies, which can be supplied via hybridoma generation. Hybridomas are hybrid cell lines f...

Particle Focusing and Separation through Lab-On-Chip Device by Dielectrophoresis

A Lab-On-Chip micro-device has been introduced for the focusing and separation of particles which exploits negative dielectrophoretic (nDEP) force. A 3D numerical computational model was presented to simulate the focusing and separation process. In particular, the model will solve for bioparticle movement and Joule heating. In the experimental study, the mixture of viable and nonviable yeast ce...